Educational Case: Granulocyte Transfusion

Granulocyte transfusion in children.

We describe a single institution experience with the use of granulocyte transfusion in children. This is a retrospective analysis of 45 collections of granulocyte units obtained by apheresis after priming with dexamethasone, infused into 17 children with severe neutropenic infections. Ten children survived the acute infection. Granulocyte transfusion is a useful adjunct to antimicrobials and gr...

Alloimmunization following prophylactic granulocyte transfusion.

Nineteen noninfected adults receiving initial induction chemotherapy for acute nonlymphocytic leukemia (ANLL) were randomized to receive either prophylactic granulocyte transfusion or platelet transfusion alone on an alternate-day schedule. An average of 11 granulocyte transfusions (range 3--19) were administered/patient with a mean dose of 11.5 X 10(9) granulocytes/transfusion. The groups were...

ABC of Transfusion. Platelet and granulocyte transfusions.

Multiple.packs for collection of blood. Left to right: transfer pack containing optimal additive solution; primary pack containing 450 ml of blood in anticoagulant; and pack for collection of platelets with extended shelf ife. Transfusion of platelets and granulocytes may be needed for patients with life threatening thrombocytopenia and neutropenia caused by bone marrow failure. These may be th...

Granulocyte transfusion therapy: randomization after all?

A practical guide to granulocyte transfusion therapy.

A major development for the supportive care of patients with bone marrow suppression has been the recent introduction of techniques for collecting granulocytes from suitable donors. There is increasing awareness in this country that granulocyte transfusion for infected neutropenic patients is now a practical possibility, and the demand for granulocytes from those centres able to provide this se...